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Replacing pressure driven flow with electroosmotic flow in
chromatography with capillary columns offers a new and powerful
approach to combine the separation power of HPLC, CE and microfluidics
devices. Having solved numerous technical hurdles, a new tool,
capillary electrochromatography (CEC), is emerging for the
analysis of complex biological mixtures. Separation efficiencies
are expected to be several orders of magnitude higher than
that of present chromatographic systems. To be successful,
this new technique requires elucidation of the fundamental
electrokinetic transport phenomena in porous media at high
electric field strength, representing one of the cores of
our research activities. Furthermore, novel solvent systems
especially designed for CEC are needed to exploit the potential
of the technique, in particular when interfacing with MS.
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projects
Theoretical
and Practical Aspects of Capillary Elektrochromatography
