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The goal of the Horváth Laboratory of Bioseparation Sciences is to expand the scope of novel innovative
and high performance bioanalytical techniques in the fields of medicine and life sciences, using high performance
single- and multi-dimensional separation methods, such as liquid chromatography (HPLC), capillary electrophoresis
(CE), capillary electrochromatography (CEC) and microfabricated devices preferably connected to mass spectroscopy
(MS). The requirement is engendered by the recent need to study global changes in expression of nucleic acids
(genomics), proteins (proteomics) and and the important post translational modification of glycosylation (glycomics).
One of the main focuses of our research program is the establishment of a solid theoretical understanding of the
physico-chemical underpinning of the differential migration processes that are involved in micro-channel based
bioanalytical techniques of great potential, like microbore-liquid chromatography, capillary electrophoresis,
capillary electrochromatography and microfabricated separation devices. Our fundamental studies on the theory
and applications are expected to support the design, preparation and use of new column technologies and stationary
phases we plan to tailor make in the Laboratory. The results of our theoretical studies together with the expertise
of the principal investigators in chromatography, column engineering, capillary electrophoresis and microfabricated
device technologies will be utilized in embarking on recent bioanalytical challenges, and upon success it is
expected to have a great impact on the way in which various diseases will be diagnosed and treated. The advent
of microfluidic-based rapid analytical techniques opens up new horizons in the biomedical field as capable of
revealing global changes in gene expression at the transcriptome, proteome and glycome level. Our endeavor will
be supported by faculty members in collaborative institutions and industrial partners.
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projects
Glycomics: UNDER CONSTRUCTION 
